Microbial Metabolites

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Prompt

Create a detailed, publication-quality scientific figure titled “Translational Potential of Microbial Metabolites in Parkinson’s Disease,” divided into three distinct vertical panels: Left Panel: Biomarkers Show microbial metabolites such as butyrate (SCFA), indole-3-propionic acid (IPA), succinate, TMAO, lithocholic acid (LCA), and putrescine as biomarkers in stool, serum, and CSF. Use labeled vials or diagnostic icons to represent clinical detection for diagnosis or patient stratification. Central Panel: Microbial Metabolite–Gut–Immune–Brain Axis Depict microbes inside the gut lumen, secreting labeled metabolites. Show these metabolites acting on gut epithelium (tight junctions), immune cells (Tregs, Th17, macrophages), and crossing the blood–brain barrier to reach the CNS. Include immune modulation arrows and label key pathways (AhR, SUCNR1, GPR43, TMA lyase). Depict α-synuclein aggregation (Lewy bodies) as spiral fibrillar structures originating in the enteric nervous system (ENS), propagating via a clearly drawn, labeled vagus nerve to the brainstem and substantia nigra. Clearly label microglia, blood–brain barrier, and neuroinflammation in the CNS. Right Panel: Therapeutic Strategies Include dietary (fiber, polyphenols), microbiota-based (probiotics, FMT), and drug-based (SUCNR1 antagonists, TMA lyase inhibitors, HDAC inhibitors, AhR ligands) interventions. Use accurate icons such as capsules, syringes, FMT bag, gut barrier reinforcement, brain scan. Show arrows linking interventions to restoration of metabolite balance and reduction of inflammation/neurodegeneration. Design Specifications: Use clear, scientific typography with zero spelling errors. Avoid artistic decoration — use minimalistic, vector-based, anatomically accurate icons. Match the style and quality of Nature Reviews Neurology figures. Use color-coding for metabolite types (e.g., SCFAs = orange, tryptophan = violet, bile acids = green), immune cells (blue), Lewy bodies (dark red), and signaling arrows (gradient directional flow). Leave no panels clipped; preserve white margins; ensure all elements are perfectly aligned. Overall size: Full A4 width, ~50–60% vertical height.